Two students--easy-going and not terribly academically inclined Toby and unpopular teacher's pet Elizabeth--are hit by an unusual magnetic pulse that transforms them both into scientific geniuses. While Toby is uncomfortable with his new power and not certain how to put it to use, Elizabeth revels in hers, hoping to dominate the school.

Creator Jonathan M. Shiff notes (in the media kit for season one) that

'I wanted the series to be grounded in real teenagers and an authentic school environment - bringing the chaos of teenage emotions and friendship to the backdrop of science and adventure. Wicked Science is very much driven by Elizabeth's desire to catch Toby's attention and instead of witchcraft or magic it is science she uses as the tool'.

The production company also liased with Australian Teachers of Media (ATOM) to create a study guide that would enable teachers to use Wicked Science as a starting point for classroom discussions of science, its place in society, and the specific scientific concepts explored in the series.